Chromosomal damage in sperm of patients surviving Hodgkin's disease following MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone) therapy with …
BF Brandriff, ML Meistrich, LA Gordon, AV Carrano… - Human genetics, 1994 - Springer
BF Brandriff, ML Meistrich, LA Gordon, AV Carrano, JC Liang
Human genetics, 1994•SpringerFollowing fusion with hamster eggs, human sperm chromosomes from six Hodgkin's disease
patients were analyzed to determine the genotoxic effects of therapy. Each patient had
received two to six cycles of MOPP (nitrogen mustard, vincristine, procarbazine, and
prednisone), with or without radiotherapy, from 3 to 20 years before the study. A total of 571
cells from the six patients were analyzed; 9.8% of the cells had structural aberrations, and
1.6% were hyperhaploid. Analysis of 5998 metaphases from a control group of 24 male …
patients were analyzed to determine the genotoxic effects of therapy. Each patient had
received two to six cycles of MOPP (nitrogen mustard, vincristine, procarbazine, and
prednisone), with or without radiotherapy, from 3 to 20 years before the study. A total of 571
cells from the six patients were analyzed; 9.8% of the cells had structural aberrations, and
1.6% were hyperhaploid. Analysis of 5998 metaphases from a control group of 24 male …
Abstract
Following fusion with hamster eggs, human sperm chromosomes from six Hodgkin's disease patients were analyzed to determine the genotoxic effects of therapy. Each patient had received two to six cycles of MOPP (nitrogen mustard, vincristine, procarbazine, and prednisone), with or without radiotherapy, from 3 to 20 years before the study. A total of 571 cells from the six patients were analyzed; 9.8% of the cells had structural aberrations, and 1.6% were hyperhaploid. Analysis of 5998 metaphases from a control group of 24 male donors revealed only 6.9% of cells with structural aberrations and 0.8% aneuploidy. The increase in hyperhaploidy in the patients was statistically significant. Thus, results of this study suggest that the MOPP regimen, with or without radiotherapy, is capable of causing chromosome abnormalities in the sperm of Hodgkin's disease patients.
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