Spatial memory, recognition memory, and the hippocampus

NJ Broadbent, LR Squire… - Proceedings of the …, 2004 - National Acad Sciences
NJ Broadbent, LR Squire, RE Clark
Proceedings of the National Academy of Sciences, 2004National Acad Sciences
There is wide agreement that spatial memory is dependent on the integrity of the
hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of
object recognition memory is not as clear. We examined the relationship between
hippocampal lesion size and both spatial memory and object recognition memory in rats.
Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed
30-50% total volume, and as lesion size increased from 50% to≈ 100% of total …
There is wide agreement that spatial memory is dependent on the integrity of the hippocampus, but the importance of the hippocampus for nonspatial tasks, including tasks of object recognition memory is not as clear. We examined the relationship between hippocampal lesion size and both spatial memory and object recognition memory in rats. Spatial memory was impaired after bilateral dorsal hippocampal lesions that encompassed 30-50% total volume, and as lesion size increased from 50% to ≈100% of total hippocampal volume, performance was similarly impaired. In contrast, object recognition was intact after dorsal hippocampal lesions that damaged 50-75% of total hippocampal volume and was impaired only after larger lesions that encompassed 75-100% of hippocampal volume. Last, ventral hippocampal lesions that encompassed ≈50% of total hippocampal volume impaired spatial memory but did not affect object recognition memory. These findings show that the hippocampus is important for both spatial memory and recognition memory. However, spatial memory performance requires more hippocampal tissue than does recognition memory.
National Acad Sciences