Liver X receptors are regulators of adipocyte gene expression but not differentiation: identification of apoD as a direct target
S Hummasti, BA Laffitte, MA Watson, C Galardi… - Journal of Lipid …, 2004 - ASBMB
The liver X receptors α and β (LXRα and LXRβ) have been shown to play important roles in
lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not
well defined. Both LXRs are highly expressed in fat, and the expression of LXRα increases
during adipogenesis. Furthermore, LXRα expression is induced by peroxisome proliferator-
activated receptor γ (PPARγ), the master regulator of fat cell differentiation. Here we
investigate the role of LXRs in adipocyte differentiation and gene expression and their …
lipid homeostasis in liver and macrophages, however, their function in adipose tissue is not
well defined. Both LXRs are highly expressed in fat, and the expression of LXRα increases
during adipogenesis. Furthermore, LXRα expression is induced by peroxisome proliferator-
activated receptor γ (PPARγ), the master regulator of fat cell differentiation. Here we
investigate the role of LXRs in adipocyte differentiation and gene expression and their …
