C/EBPα regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism: cross-talk between C/EBP pathway and iron metabolism
B Courselaud, C Pigeon, Y Inoue, J Inoue… - Journal of Biological …, 2002 - ASBMB
Originally identified as a gene up-regulated by iron overload in mouse liver, the HEPC gene
encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key
regulator of iron metabolism. Here we demonstrate that during rat liver development,
amounts of HEPC transcripts were very low in fetal liver, strongly and transiently increased
shortly after birth, and reappeared in adult liver. To gain insight into mechanisms that
regulate hepatic expression of hepcidin, 5′-flanking regions of human and mouse HEPC …
encodes hepcidin, the first mammalian liver-specific antimicrobial peptide and potential key
regulator of iron metabolism. Here we demonstrate that during rat liver development,
amounts of HEPC transcripts were very low in fetal liver, strongly and transiently increased
shortly after birth, and reappeared in adult liver. To gain insight into mechanisms that
regulate hepatic expression of hepcidin, 5′-flanking regions of human and mouse HEPC …
