Peroxisome proliferator-activated receptor-γ represses GLUT4 promoter activity in primary adipocytes, and rosiglitazone alleviates this effect
M Armoni, N Kritz, C Harel, F Bar-Yoseph… - Journal of Biological …, 2003 - ASBMB
The synthetic thiazolidinedione ligands of peroxisome proliferator-activated receptor-γ
(PPARγ) improve insulin sensitivity in type II diabetes and induce GLUT4 mRNA expression
in fat and muscle. However, the molecular mechanisms involved are still unclear. We
studied the regulatory effects of PPARγ and its ligands on GLUT4 gene expression in
primary rat adipocytes and CHO-K1 cells cotransfected with PPARγ and the GLUT4
promoter reporter. PPARγ1 and PPARγ2 repressed the activity of the GLUT4 promoter in a …
(PPARγ) improve insulin sensitivity in type II diabetes and induce GLUT4 mRNA expression
in fat and muscle. However, the molecular mechanisms involved are still unclear. We
studied the regulatory effects of PPARγ and its ligands on GLUT4 gene expression in
primary rat adipocytes and CHO-K1 cells cotransfected with PPARγ and the GLUT4
promoter reporter. PPARγ1 and PPARγ2 repressed the activity of the GLUT4 promoter in a …