Physiological mechanisms regulating the expression of endothelial-type NO synthase
H Li, T Wallerath, U Förstermann - Nitric oxide, 2002 - Elsevier
Although endothelial nitric oxide synthase (eNOS) is a constitutively expressed enzyme, its
expression is regulated by a number of biophysical, biochemical, and hormonal stimuli, both
under physiological conditions and in pathology. This review summarizes the recent findings
in this field. Shear stress, growth factors (such as transforming growth factor-β, fibroblast
growth factor, vascular endothelial growth factor, and platelet-derived growth factor),
hormones (such as estrogens, insulin, angiotensin II, and endothelin 1), and other …
expression is regulated by a number of biophysical, biochemical, and hormonal stimuli, both
under physiological conditions and in pathology. This review summarizes the recent findings
in this field. Shear stress, growth factors (such as transforming growth factor-β, fibroblast
growth factor, vascular endothelial growth factor, and platelet-derived growth factor),
hormones (such as estrogens, insulin, angiotensin II, and endothelin 1), and other …
