[HTML][HTML] Regulation of Expression of ob mRNA and Protein by Glucocorticoids and cAMP (∗)
LJ Slieker, KW Sloop, PL Surface, A Kriauciunas… - Journal of Biological …, 1996 - ASBMB
Regulation of obese gene (ob) expression in ob/ob and db/db mice and in cultured rat
adipocytes was examined. It has been demonstrated that exogenous human OB protein
(leptin) treatment reduces food intake and weight gain, as well as insulin, glucose, and
corticosterone levels in ob/ob mice. In the present report we show that leptin treatment down-
regulates endogenous adipose ob mRNA. However, treatment of isolated rat adipocytes
with 100 ng/ml human or murine leptin had no direct effect on expression of endogenous ob …
adipocytes was examined. It has been demonstrated that exogenous human OB protein
(leptin) treatment reduces food intake and weight gain, as well as insulin, glucose, and
corticosterone levels in ob/ob mice. In the present report we show that leptin treatment down-
regulates endogenous adipose ob mRNA. However, treatment of isolated rat adipocytes
with 100 ng/ml human or murine leptin had no direct effect on expression of endogenous ob …
