Vitamin K counteracts the effect of warfarin in liver but not in bone
PA Price, Y Kaneda - Thrombosis research, 1987 - Elsevier
Abstract Treatment with high dosages of Vitamin K completely inhibited the effect of Warfarin
on blood coagulation but had essentially no ability to counteract the effect of Warfarin on the
γ-carboxylation of bone G1a protein (BGP; osteocalcin). Provided that rats received the
appropriate dosage of Vitamin K prior to and concurrent with the administration of Warfarin,
daily dosages as high as 7.7 mg Warfarin per 100 g body weight had no effect on blood
coagulation times. This Warfarin dosage is approximately 150 times higher than the 50 μg …
on blood coagulation but had essentially no ability to counteract the effect of Warfarin on the
γ-carboxylation of bone G1a protein (BGP; osteocalcin). Provided that rats received the
appropriate dosage of Vitamin K prior to and concurrent with the administration of Warfarin,
daily dosages as high as 7.7 mg Warfarin per 100 g body weight had no effect on blood
coagulation times. This Warfarin dosage is approximately 150 times higher than the 50 μg …