Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate …
D Marchetti, GL Nicolson - Advances in enzyme regulation, 1997 - Elsevier
Heparanase is an endo-β-d-glucuronidase whose enzymatic targets are the
glycosaminoglycan chains of heparan sulfate proteoglycans (50). Elevated levels of
heparanase are associated with the metastatic potential of melanoma cells, and treatment of
murine and human melanoma cells with the prototypic neurotrophin nerve growth factor
(NGF) increases the production of heparanase by melanoma cells. We previously reported
that physiological concentrations of NGF increased invasion of early passage human brain …
glycosaminoglycan chains of heparan sulfate proteoglycans (50). Elevated levels of
heparanase are associated with the metastatic potential of melanoma cells, and treatment of
murine and human melanoma cells with the prototypic neurotrophin nerve growth factor
(NGF) increases the production of heparanase by melanoma cells. We previously reported
that physiological concentrations of NGF increased invasion of early passage human brain …
