[HTML][HTML] KGF induces lipogenic genes through a PI3K and JNK/SREBP-1 pathway in H292 cells
Y Chang, J Wang, X Lu, DP Thewke, RJ Mason - Journal of lipid research, 2005 - ASBMB
Lipid synthesis is required for cell growth and is subject to pharmacologic regulation.
Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a
pulmonary epithelial cancer cell line, but the signaling pathways are not known. KGF
stimulated the expression of the transcription factors sterol-regulatory element binding
protein-1 (SREBP-1), CCAAT/enhancer binding protein α (C/EBPα), and C/EBPδ and two
key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1) …
Keratinocyte growth factor (KGF) stimulates proliferation and lipogenesis in H292 cells, a
pulmonary epithelial cancer cell line, but the signaling pathways are not known. KGF
stimulated the expression of the transcription factors sterol-regulatory element binding
protein-1 (SREBP-1), CCAAT/enhancer binding protein α (C/EBPα), and C/EBPδ and two
key enzymes involved in lipogenesis, FAS and stearoyl coenzyme A desaturase-1 (SCD-1) …