Oxygen sensing, HIF-1α stabilization and potential therapeutic strategies.
T Hofer, RH Wenger… - Pflügers Archiv: European …, 2002 - search.ebscohost.com
T Hofer, RH Wenger, M Gassmann
Pflügers Archiv: European Journal of Physiology, 2002•search.ebscohost.comThis article focuses on the latest developments in oxygen sensing and oxygen-regulated
gene expression. The transcription factor hypoxia-inducible factor-1 (HIF-1) has emerged as
a key regulator of oxygen homeostasis. It consists of HIF-1& b. alpha and HIF-1&
b. alpha;/ARNT (aryl hydrocarbon receptor nuclear translocator) subunits, both belonging to
the PAS (Per-ARNT/AhR-Sim) subfamily of basic helixloop-helix transcription factors [32].
Above a critical intracellular oxygen partial pressure, HIF-1& b. alpha; protein is …
gene expression. The transcription factor hypoxia-inducible factor-1 (HIF-1) has emerged as
a key regulator of oxygen homeostasis. It consists of HIF-1& b. alpha and HIF-1&
b. alpha;/ARNT (aryl hydrocarbon receptor nuclear translocator) subunits, both belonging to
the PAS (Per-ARNT/AhR-Sim) subfamily of basic helixloop-helix transcription factors [32].
Above a critical intracellular oxygen partial pressure, HIF-1& b. alpha; protein is …
Abstract
This article focuses on the latest developments in oxygen sensing and oxygen-regulated gene expression. The transcription factor hypoxia-inducible factor-1 (HIF-1) has emerged as a key regulator of oxygen homeostasis. It consists of HIF-1& b. alpha and HIF-1& b. alpha;/ARNT (aryl hydrocarbon receptor nuclear translocator) subunits, both belonging to the PAS (Per-ARNT/AhR-Sim) subfamily of basic helixloop-helix transcription factors [32]. Above a critical intracellular oxygen partial pressure, HIF-1& b. alpha; protein is maintained at low and often undetectable levels.
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