[HTML][HTML] Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates β-catenin signaling and NFκB-specific transcription activity leading to MDR1 and Bcl …
LYW Bourguignon, W Xia, G Wong - Journal of biological chemistry, 2009 - ASBMB
In this study we have investigated hyaluronan (HA)-mediated CD44 (an HA receptor)
interactions with p300 (a histone acetyltransferase) and SIRT1 (a histone deacetylase) in
human breast tumor cells (MCF-7 cells). Specifically, our results indicate that HA binding to
CD44 up-regulates p300 expression and its acetyltransferase activity that, in turn, promotes
acetylation of β-catenin and NFκB-p65 leading to activation of β-catenin-associated T-cell
factor/lymphocyte enhancer factor transcriptional co-activation and NFκB-specific …
interactions with p300 (a histone acetyltransferase) and SIRT1 (a histone deacetylase) in
human breast tumor cells (MCF-7 cells). Specifically, our results indicate that HA binding to
CD44 up-regulates p300 expression and its acetyltransferase activity that, in turn, promotes
acetylation of β-catenin and NFκB-p65 leading to activation of β-catenin-associated T-cell
factor/lymphocyte enhancer factor transcriptional co-activation and NFκB-specific …
