[HTML][HTML] Glucocorticoids regulate transcription of the gene for phosphoenolpyruvate carboxykinase in the liver via an extended glucocorticoid regulatory unit
H Cassuto, K Kochan, K Chakravarty, H Cohen… - Journal of Biological …, 2005 - ASBMB
The hepatic transcriptional regulation by glucocorticoids of the cytosolic form of
phosphoenolpyruvate carboxykinase (PEPCK-C) gene is coordinated by interactions of
specific transcription factors at the glucocorticoid regulatory unit (GRU). We propose an
extended GRU that consists of four accessory sites, two proximal AF1 and AF2 sites and
their distal counterpart dAF1 (–993) and a new site, dAF2 (–1365); together, these four sites
form a palindrome. Sequencing and gel shift binding assays of hepatic nuclear proteins …
phosphoenolpyruvate carboxykinase (PEPCK-C) gene is coordinated by interactions of
specific transcription factors at the glucocorticoid regulatory unit (GRU). We propose an
extended GRU that consists of four accessory sites, two proximal AF1 and AF2 sites and
their distal counterpart dAF1 (–993) and a new site, dAF2 (–1365); together, these four sites
form a palindrome. Sequencing and gel shift binding assays of hepatic nuclear proteins …