Estrogen and CD4+ T cells
AB Pernis - Current opinion in rheumatology, 2007 - journals.lww.com
AB Pernis
Current opinion in rheumatology, 2007•journals.lww.comDissecting the molecular pathways employed by estrogen to modulate CD4+ T cells will be
critical in elucidating the manner by which estrogen exerts its effects on this compartment.
Given that cell type specific differences underlie the ability of many hormonal therapies to
exert tissue-specific estrogenic or antiestrogenic activities, this knowledge will be crucial to
further exploitation of hormonal therapies in rheumatic autoimmune diseases.
critical in elucidating the manner by which estrogen exerts its effects on this compartment.
Given that cell type specific differences underlie the ability of many hormonal therapies to
exert tissue-specific estrogenic or antiestrogenic activities, this knowledge will be crucial to
further exploitation of hormonal therapies in rheumatic autoimmune diseases.
Summary
Dissecting the molecular pathways employed by estrogen to modulate CD4+ T cells will be critical in elucidating the manner by which estrogen exerts its effects on this compartment. Given that cell type specific differences underlie the ability of many hormonal therapies to exert tissue-specific estrogenic or antiestrogenic activities, this knowledge will be crucial to further exploitation of hormonal therapies in rheumatic autoimmune diseases.
Lippincott Williams & Wilkins