Human neural stem cells improve cognitive function of aged brain
T Qu, CL Brannen, HM Kim, K Sugaya - Neuroreport, 2001 - journals.lww.com
The capability for in vitro expansion of human neural stem cells (HNSCs) provides a well
characterized and unlimited source alternative to using primary fetal tissue for neuronal
replacement therapies. The HNSCs, injected into the lateral ventricle of 24-month-old rats
after in vitro expansion, displayed extensive and positional incorporation into the aged host
brain with improvement of cognitive score assessed by the Morris water maze after 4 weeks
of the transplantation. Our results demonstrate that the aged brain is capable of providing …
characterized and unlimited source alternative to using primary fetal tissue for neuronal
replacement therapies. The HNSCs, injected into the lateral ventricle of 24-month-old rats
after in vitro expansion, displayed extensive and positional incorporation into the aged host
brain with improvement of cognitive score assessed by the Morris water maze after 4 weeks
of the transplantation. Our results demonstrate that the aged brain is capable of providing …