Identification and Cloning of the Human Homolog (JAG1) of the RatJagged1Gene from the Alagille Syndrome Critical Region at 20p12
T Oda, AG Elkahloun, PS Meltzer… - Genomics, 1997 - Elsevier
T Oda, AG Elkahloun, PS Meltzer, SC Chandrasekharappa
Genomics, 1997•ElsevierNotch proteins are a family of closely related transmembrane receptors proven to be
instrumental in cell fate decisions. Recently, Notch ligands Delta and Jagged have been
identified inDrosophilaand rat, respectively. We have isolated the human homolog of the
ratJagged1gene, JAG1, from a CpG island in a YAC clone covering the Alagille syndrome
critical region at chromosome 20p12 (tel–SNAP–D20S186–cen). Alagille syndrome is an
autosomal dominant disorder characterized by neonatal jaundice, paucity of intrahepatic …
instrumental in cell fate decisions. Recently, Notch ligands Delta and Jagged have been
identified inDrosophilaand rat, respectively. We have isolated the human homolog of the
ratJagged1gene, JAG1, from a CpG island in a YAC clone covering the Alagille syndrome
critical region at chromosome 20p12 (tel–SNAP–D20S186–cen). Alagille syndrome is an
autosomal dominant disorder characterized by neonatal jaundice, paucity of intrahepatic …
Notch proteins are a family of closely related transmembrane receptors proven to be instrumental in cell fate decisions. Recently, Notch ligands Delta and Jagged have been identified inDrosophilaand rat, respectively. We have isolated the human homolog of the ratJagged1gene,JAG1,from a CpG island in a YAC clone covering the Alagille syndrome critical region at chromosome 20p12 (tel–SNAP–D20S186–cen). Alagille syndrome is an autosomal dominant disorder characterized by neonatal jaundice, paucity of intrahepatic bile ducts, and abnormalities of the heart, skeleton, and eyes. The humanJagged1(JAG1), therefore, appears to be a strong candidate gene for this disease. Here we describe the identification, full-length cDNA cloning, expression patterns, and precise physical location of this gene within the Alagille syndrome critical region.
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