[HTML][HTML] Differential association of phosphodiesterase 4D isoforms with β2-adrenoceptor in cardiac myocytes
V De Arcangelis, R Liu, D Soto, Y Xiang - Journal of biological chemistry, 2009 - ASBMB
cAMP and protein kinase A (PKA) activation represents a key signaling mechanism upon β-
adrenergic stimulation under stress. Both β 1-and β 2-adrenoreceptor (ARs) subtypes
induce cAMP accumulation, yet play distinct roles in cardiac contraction and myocyte
apoptosis. Differences in controlling cAMP/PKA activities through the assembly of
complexes between the receptors and cAMP-specific phosphodiesterases contribute to the
distinct biological outcomes. Here, we demonstrate that β 2 ARs form signaling complexes …
adrenergic stimulation under stress. Both β 1-and β 2-adrenoreceptor (ARs) subtypes
induce cAMP accumulation, yet play distinct roles in cardiac contraction and myocyte
apoptosis. Differences in controlling cAMP/PKA activities through the assembly of
complexes between the receptors and cAMP-specific phosphodiesterases contribute to the
distinct biological outcomes. Here, we demonstrate that β 2 ARs form signaling complexes …