Krüppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation
PM Evans, W Zhang, X Chen, J Yang, KK Bhakat… - Journal of biological …, 2007 - ASBMB
Colon cancer is the second leading cause of cancer death in the United States. Krüppel-like
factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the
colon. It is down-regulated in both mouse and human colonic adenomas and has been
implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an
oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem
cells. KLF4 can act as a transcriptional activator or repressor, but the underlying …
factor 4 (KLF4) is a transcription factor involved in both proliferation and differentiation in the
colon. It is down-regulated in both mouse and human colonic adenomas and has been
implicated as a tumor suppressor in the gut, whereas in breast cancer, KLF4 is an
oncogene. KLF4 is also involved in reprogramming differentiated cells into pluripotent stem
cells. KLF4 can act as a transcriptional activator or repressor, but the underlying …
