[HTML][HTML] Molecular basis for zinc transporter 1 action as an endogenous inhibitor of L-type calcium channels
S Levy, O Beharier, Y Etzion, M Mor, L Buzaglo… - Journal of biological …, 2009 - ASBMB
The L-type calcium channel (LTCC) has a variety of physiological roles that are critical for
the proper function of many cell types and organs. Recently, a member of the zinc-regulating
family of proteins, ZnT-1, was recognized as an endogenous inhibitor of the LTCC, but its
mechanism of action has not been elucidated. In the present study, using two-electrode
voltage clamp recordings in Xenopus oocytes, we demonstrate that ZnT-1-mediated
inhibition of the LTCC critically depends on the presence of the LTCC regulatory β-subunit …
the proper function of many cell types and organs. Recently, a member of the zinc-regulating
family of proteins, ZnT-1, was recognized as an endogenous inhibitor of the LTCC, but its
mechanism of action has not been elucidated. In the present study, using two-electrode
voltage clamp recordings in Xenopus oocytes, we demonstrate that ZnT-1-mediated
inhibition of the LTCC critically depends on the presence of the LTCC regulatory β-subunit …