Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis
T Krüger, D Benke, F Eitner, A Lang… - Journal of the …, 2004 - journals.lww.com
The kidney tubulointerstitium contains numerous bone marrow-derived antigen-presenting
cells, which are often referred to as resident tissue macrophages, although several previous
studies had demonstrated characteristics of dendritic cells (DC). In this study, we describe a
subset of tubulointerstitial cells expressing the DC marker CD11c. A protocol was
established to isolate these cells for in vitro analysis. Renal CD11c+ cells resembled splenic
DC, but not peritoneal macrophages, in morphology, lysosomal content, phagocytic activity …
cells, which are often referred to as resident tissue macrophages, although several previous
studies had demonstrated characteristics of dendritic cells (DC). In this study, we describe a
subset of tubulointerstitial cells expressing the DC marker CD11c. A protocol was
established to isolate these cells for in vitro analysis. Renal CD11c+ cells resembled splenic
DC, but not peritoneal macrophages, in morphology, lysosomal content, phagocytic activity …