[HTML][HTML] Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa
Vaccine, 2009•Elsevier
Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the
impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using
STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years
with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75%
for 10 years, reduced HIV incidence by 30–40% after 20 years (range 4–66%). Over 20
years, in most scenarios fewer than 100 vaccinations were required to avert one HIV …
impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using
STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years
with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75%
for 10 years, reduced HIV incidence by 30–40% after 20 years (range 4–66%). Over 20
years, in most scenarios fewer than 100 vaccinations were required to avert one HIV …
Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model. A campaign that achieved 70% coverage over 5 years with a vaccine that reduced susceptibility to HSV2 acquisition and HSV2 reactivation by 75% for 10 years, reduced HIV incidence by 30–40% after 20 years (range 4–66%). Over 20 years, in most scenarios fewer than 100 vaccinations were required to avert one HIV infection. HSV2 vaccines could have a substantial impact on HIV incidence. Intensified efforts are needed to develop an effective HSV2 vaccine.
Elsevier