Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs)
L Premkumar, AA Bobkov, M Patel… - Journal of biological …, 2010 - ASBMB
The Dock180 family of atypical Rho family guanine nucleotide exchange factors (Rho-GEFs)
regulate a variety of processes involving cellular or subcellular polarization, including cell
migration and phagocytosis. Each contains a Dock homology region-1 (DHR-1) domain that
is required to localize its GEF activity to a specific membrane compartment where levels of
phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns (3, 4, 5) P 3) are up-regulated by the local
activity of PtdIns 3-kinase. Here we define the structural and energetic bases of …
regulate a variety of processes involving cellular or subcellular polarization, including cell
migration and phagocytosis. Each contains a Dock homology region-1 (DHR-1) domain that
is required to localize its GEF activity to a specific membrane compartment where levels of
phosphatidylinositol (3, 4, 5)-trisphosphate (PtdIns (3, 4, 5) P 3) are up-regulated by the local
activity of PtdIns 3-kinase. Here we define the structural and energetic bases of …
