[PDF][PDF] Neural coding: hybrid analog and digital signalling in axons

B Clark, M Häusser - Current biology, 2006 - cell.com
Current biology, 2006cell.com
Mammalian axons are thought to act as digital signaling devices, conveying information only
by the timing and rate of all-or-none action potentials. Two recent studies now show that
synaptic potentials can also spread far down the axon and influence action potential-
triggered transmitter release in a graded,'analog'manner. Axons thus encode information
both about subthreshold and suprathreshold synaptic activity.
Mammalian axons are thought to act as digital signaling devices, conveying information only by the timing and rate of all-or-none action potentials. Two recent studies now show that synaptic potentials can also spread far down the axon and influence action potential-triggered transmitter release in a graded, ‘analog' manner. Axons thus encode information both about subthreshold and suprathreshold synaptic activity.
cell.com