Innate (inherent) control of brain infection, brain inflammation and brain repair: the role of microglia, astrocytes,“protective” glial stem cells and stromal ependymal cells
M Hauwel, E Furon, C Canova, M Griffiths, J Neal… - Brain research …, 2005 - Elsevier
In invertebrates and primitive vertebrates, the brain contains large numbers of “professional”
macrophages associated with neurones, ependymal tanycytes and radial glia to promote
robust regenerative capacity. In higher vertebrates, hematogenous cells are largely
excluded from the brain, and innate immune molecules and receptors produced by the
resident “amateur” macrophages (microglia, astrocytes and ependymal cells) control
pathogen infiltration and clearance of toxic cell debris. However, there is minimal capacity …
macrophages associated with neurones, ependymal tanycytes and radial glia to promote
robust regenerative capacity. In higher vertebrates, hematogenous cells are largely
excluded from the brain, and innate immune molecules and receptors produced by the
resident “amateur” macrophages (microglia, astrocytes and ependymal cells) control
pathogen infiltration and clearance of toxic cell debris. However, there is minimal capacity …