Characterization and immune function of two intracellular sensors, HmTLR1 and HmNLR, in the injured CNS of an invertebrate
V Cuvillier-Hot, C Boidin-Wichlacz, C Slomianny… - Developmental & …, 2011 - Elsevier
Unlike mammals, the CNS of the medicinal leech can regenerate damaged neurites, thus
restoring neural functions. Our group recently demonstrated that the injured leech nerve
cord is able to mount an immune response, which promotes the regenerative processes.
This defense mechanism is microorganism-specific, suggesting that the leech CNS is able to
discriminate among microbial components. We report here the characterization of two
receptors potentially implicated in this detection: HmTLR1 and HmNLR. Interestingly …
restoring neural functions. Our group recently demonstrated that the injured leech nerve
cord is able to mount an immune response, which promotes the regenerative processes.
This defense mechanism is microorganism-specific, suggesting that the leech CNS is able to
discriminate among microbial components. We report here the characterization of two
receptors potentially implicated in this detection: HmTLR1 and HmNLR. Interestingly …