Fixing ryanodine receptor Ca2+ leak–a novel therapeutic strategy for contractile failure in heart and skeletal muscle
DC Andersson, AR Marks - Drug discovery today: disease mechanisms, 2010 - Elsevier
A crucial component in regulating cardiac and skeletal muscles contractility is the release of
Ca2+ via ryanodine receptor (RyR) Ca2+ release channels in the sarcoplasmic reticulum
(SR). In heart failure and myopathy, the RyR has been found to be excessively
phosphorylated or nitrosylated and depleted of the RyR-stabilizing protein calstabin (FK506
binding protein 12/12.6). This remodeling of the RyR channel complex results in an
intracellular SR Ca2+ leak and impaired contractility. Despite recent advances in heart …
Ca2+ via ryanodine receptor (RyR) Ca2+ release channels in the sarcoplasmic reticulum
(SR). In heart failure and myopathy, the RyR has been found to be excessively
phosphorylated or nitrosylated and depleted of the RyR-stabilizing protein calstabin (FK506
binding protein 12/12.6). This remodeling of the RyR channel complex results in an
intracellular SR Ca2+ leak and impaired contractility. Despite recent advances in heart …
