[HTML][HTML] Cholesteryl ester transfer protein inhibition as a strategy to reduce cardiovascular risk
Human and rabbit plasma contain a cholesteryl ester transfer protein (CETP) that promotes
net mass transfers of cholesteryl esters from high density lipoproteins (HDL) to other plasma
lipoprotein fractions. As predicted, inhibition of CETP in both humans and rabbits increases
the concentration of cholesterol in the potentially protective HDL fraction, while decreasing it
in potentially proatherogenic non-HDL fractions. Inhibition of CETP in rabbits also inhibits
the development of diet-induced atherosclerosis. However, use of the CETP inhibitor …
net mass transfers of cholesteryl esters from high density lipoproteins (HDL) to other plasma
lipoprotein fractions. As predicted, inhibition of CETP in both humans and rabbits increases
the concentration of cholesterol in the potentially protective HDL fraction, while decreasing it
in potentially proatherogenic non-HDL fractions. Inhibition of CETP in rabbits also inhibits
the development of diet-induced atherosclerosis. However, use of the CETP inhibitor …
