[HTML][HTML] Coupling in vitro and in vivo paradigm reveals a dose dependent inhibition of angiogenesis followed by initiation of autophagy by C6-ceramide
RR Bansode, M Ahmedna, KR Svoboda… - International Journal of …, 2011 - ncbi.nlm.nih.gov
RR Bansode, M Ahmedna, KR Svoboda, JN Losso
International Journal of Biological Sciences, 2011•ncbi.nlm.nih.govThe activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was
tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also
determined. The aim of this study was to potentiate the effect of ceramide as anti-angiogenic
compound that can regulate tumor induced angiogenesis.
tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also
determined. The aim of this study was to potentiate the effect of ceramide as anti-angiogenic
compound that can regulate tumor induced angiogenesis.
Abstract
The activity of N-hexanoyl-D-erythro-sphingosine, a C6-ceramide against angiogenesis was tested in vitro and in vivo. The effect of ceramide in inhibiting MCF-7 cancer cells was also determined. The aim of this study was to potentiate the effect of ceramide as anti-angiogenic compound that can regulate tumor induced angiogenesis.
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