Endogenous activation of c-myc expression and DNA synthesis in serum-starved neonatal rat smooth muscle cells
A Hultgårdh-Nilsson, U Krondahl, WQ Jiang, J Nilsson… - Differentiation, 1993 - Elsevier
Earlier studies have shown that smooth muscle cells (SMC) from arteries of neonatal and
adult rats differ markedly in their in vitro growth characteristics. Since some of these
differences may be relevant to the proliferation of SMC in atherosclerotic plaques we
examined the expression of three proto-oncogenes (c-fos, c-jun, and c-myc) and an SMC-
specific differentiation marker (α-actin) in cultured SMC. In presence of serum cultured adult
SMC contained lower levels of α-actin mRNA than neonatal cells. In neonatal cells serum …
adult rats differ markedly in their in vitro growth characteristics. Since some of these
differences may be relevant to the proliferation of SMC in atherosclerotic plaques we
examined the expression of three proto-oncogenes (c-fos, c-jun, and c-myc) and an SMC-
specific differentiation marker (α-actin) in cultured SMC. In presence of serum cultured adult
SMC contained lower levels of α-actin mRNA than neonatal cells. In neonatal cells serum …