[HTML][HTML] Hormonally active vitamin D3 (1α, 25-dihydroxycholecalciferol) triggers autophagy in human macrophages that inhibits HIV-1 infection
GR Campbell, SA Spector - Journal of Biological Chemistry, 2011 - ASBMB
Autophagy is a self-digestion pathway essential for maintaining cellular homeostasis and
cell survival and for degrading intracellular pathogens. Human immunodeficiency virus-1
(HIV-1) may utilize autophagy for replication as the autophagy-related protein-7 (ATG-7),
microtubule-associated protein 1 light chain 3, ATG-12, and ATG-16L2 are required for
productive HIV-1 infection; however, the effects of autophagy induction on HIV-1 infection
are unknown. HIV-1-infected individuals have lower levels of 1α, 25 …
cell survival and for degrading intracellular pathogens. Human immunodeficiency virus-1
(HIV-1) may utilize autophagy for replication as the autophagy-related protein-7 (ATG-7),
microtubule-associated protein 1 light chain 3, ATG-12, and ATG-16L2 are required for
productive HIV-1 infection; however, the effects of autophagy induction on HIV-1 infection
are unknown. HIV-1-infected individuals have lower levels of 1α, 25 …