[HTML][HTML] Inhibition of p66ShcA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis
M Husain, LG Meggs, H Vashistha, S Simoes… - Journal of biological …, 2009 - ASBMB
Glomerular visceral epithelial cells (podocytes) play a critical role in the pathogenesis of
human immunodeficiency virus (HIV)-associated nephropathy. A key question concerns the
mechanism (s) by which the HIV-1 genome alters the phenotype of the highly specialized,
terminally differentiated podocytes. Here, using an in vitro system of conditionally
immortalized differentiated human podocytes (CIDHPs), we document a pivotal role for the
p66ShcA protein in HIV-1-induced reactive oxygen species generation and CIDHP …
human immunodeficiency virus (HIV)-associated nephropathy. A key question concerns the
mechanism (s) by which the HIV-1 genome alters the phenotype of the highly specialized,
terminally differentiated podocytes. Here, using an in vitro system of conditionally
immortalized differentiated human podocytes (CIDHPs), we document a pivotal role for the
p66ShcA protein in HIV-1-induced reactive oxygen species generation and CIDHP …