CNS glia are targets for GDNF and neurturin
B Franke, M Figiel, J Engele - Histochemistry and cell biology, 1998 - Springer
B Franke, M Figiel, J Engele
Histochemistry and cell biology, 1998•SpringerGlial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two closely
related growth factors reported to selectively act on distinct neuronal populations in the CNS.
Both GDNF and NTN signal through a receptor complex consisting of the signal transducing
subunit, Ret, and a ligand-specific binding subunit, termed GDNF family receptor (GFR) α-1
and GFRα-2, respectively. By using RT-PCR, we observed that mRNAs encoding the
subunits of both receptor complexes are widely expressed throughout the developing brain …
related growth factors reported to selectively act on distinct neuronal populations in the CNS.
Both GDNF and NTN signal through a receptor complex consisting of the signal transducing
subunit, Ret, and a ligand-specific binding subunit, termed GDNF family receptor (GFR) α-1
and GFRα-2, respectively. By using RT-PCR, we observed that mRNAs encoding the
subunits of both receptor complexes are widely expressed throughout the developing brain …
Abstract
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two closely related growth factors reported to selectively act on distinct neuronal populations in the CNS. Both GDNF and NTN signal through a receptor complex consisting of the signal transducing subunit, Ret, and a ligand-specific binding subunit, termed GDNF family receptor (GFR)α-1 and GFRα-2, respectively. By using RT-PCR, we observed that mRNAs encoding the subunits of both receptor complexes are widely expressed throughout the developing brain, suggesting the presence of targets for these growth factors other than the ones known today. We provide evidence that these targets include glial cells.
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