Rap1a deficiency modifies cytokine responses and MAPK-signaling in vitro and impairs the in vivo inflammatory response
A Dorn, A Zoellner, M Follo, S Martin, F Weber… - Cellular …, 2012 - Elsevier
Rap1, which is closely related to ras, plays a key role in T-cell receptor (TCR)-signaling.
TCR-stimulation without costimulation leads to constitutively activated rap1, which may
mediate T-cell anergy via inhibition of ras-dependent induction of extracellular signal-
regulated kinases (ERK). This activation is mediated by a second protein kinase b-Raf.
Rap1-GTP is thought to activate ERK in a ras-independent manner by binding b-raf.
Generally, T cells do not express b-raf while they express the adaptor protein raf-1, which is …
TCR-stimulation without costimulation leads to constitutively activated rap1, which may
mediate T-cell anergy via inhibition of ras-dependent induction of extracellular signal-
regulated kinases (ERK). This activation is mediated by a second protein kinase b-Raf.
Rap1-GTP is thought to activate ERK in a ras-independent manner by binding b-raf.
Generally, T cells do not express b-raf while they express the adaptor protein raf-1, which is …
