Remyelination of the central nervous system: a valuable contribution from the periphery

V Zujovic, C Bachelin… - The …, 2007 - journals.sagepub.com
V Zujovic, C Bachelin, A Baron-Van Evercooren
The Neuroscientist, 2007journals.sagepub.com
The loss of myelin, a major element involved in the saltatory conduction of the electrical
impulse of the nervous system, is a major target of current research. Serious long-term
disabilities are observed in patients with demyelinating disease of the central nervous
system, such as multiple sclerosis. New therapeutic strategies aimed at overcoming myelin
damage and axonal loss focus on the repair potential of myelin-forming cells. This review
examines the use of peripheral myelin-forming cells, the Schwann cells, to promote myelin …
The loss of myelin, a major element involved in the saltatory conduction of the electrical impulse of the nervous system, is a major target of current research. Serious long-term disabilities are observed in patients with demyelinating disease of the central nervous system, such as multiple sclerosis. New therapeutic strategies aimed at overcoming myelin damage and axonal loss focus on the repair potential of myelin-forming cells. This review examines the use of peripheral myelin-forming cells, the Schwann cells, to promote myelin repair. NEUROSCIENTIST 13(4):383—391, 2007. DOI: 10.1177/1073858407300762
Sage Journals