In vitro cultivation of the exoerythrocytic stage of Plasmodium berghei in irradiated hepatoma cells.
MR Hollingdale, P Leland, CI Sigler - The American journal of …, 1985 - europepmc.org
MR Hollingdale, P Leland, CI Sigler
The American journal of tropical medicine and hygiene, 1985•europepmc.orgGrowth of cultures of human hepatoma cells was inhibited by exposure to doses of gamma
irradiation as low as 1,000 rad., and the monolayers remained viable for up to 35 days.
Irradiated cells were at least as susceptible to Plasmodium berghei sporozoite invasion as
non-irradiated cells, and supported the entire exoerythrocytic cycle producing more
infectious merozoites. Irradiated cultures may have use for culture of human malarias, and
drug studies requiring synchronous cultures.
irradiation as low as 1,000 rad., and the monolayers remained viable for up to 35 days.
Irradiated cells were at least as susceptible to Plasmodium berghei sporozoite invasion as
non-irradiated cells, and supported the entire exoerythrocytic cycle producing more
infectious merozoites. Irradiated cultures may have use for culture of human malarias, and
drug studies requiring synchronous cultures.
Growth of cultures of human hepatoma cells was inhibited by exposure to doses of gamma irradiation as low as 1,000 rad., and the monolayers remained viable for up to 35 days. Irradiated cells were at least as susceptible to Plasmodium berghei sporozoite invasion as non-irradiated cells, and supported the entire exoerythrocytic cycle producing more infectious merozoites. Irradiated cultures may have use for culture of human malarias, and drug studies requiring synchronous cultures.
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