[HTML][HTML] Interleukin-1 receptor antagonist induction as an additional mechanism for liver receptor homolog-1 to negatively regulate the hepatic acute phase response

N Venteclef, P Delerive - Journal of biological chemistry, 2007 - ASBMB
The liver receptor homolog-1 (LRH-1) is an orphan nuclear receptor believed to play a key
role in bile acid metabolism, cholesterol homeostasis, and intestinal cell crypt renewal. LRH-
1 has recently been reported to negatively regulate the hepatic acute phase response by
antagonizing, at least in part, the CCAAT/enhancer-binding protein signaling pathway. Here
we have shown, using adenovirus-mediated LRH-1 overexpression and gene-silencing
experiments, that the interleukin-1 receptor antagonist (IL-1RA) gene is a novel LRH-1 target …