Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia
JD Belcher, PH Marker, P Geiger, AW Girotti… - Journal of Laboratory …, 1999 - Elsevier
Patients with sickle-cell anemia exhibit pro-oxidative metabolic perturbations. We
hypothesize that because of chronic oxidative stress, plasma low-density lipoprotein (LDL)
from patients with sickle-cell anemia is more susceptible to oxidation. To test this hypothesis,
LDL susceptibility to copper-mediated oxidation was measured in 24 patients with sickle-cell
anemia and 48 control subjects. Sickle-cell LDL was more susceptible to oxidation than
control LDL, measured by a 22% shorter mean lag time between LDL exposure to CuSO4 …
hypothesize that because of chronic oxidative stress, plasma low-density lipoprotein (LDL)
from patients with sickle-cell anemia is more susceptible to oxidation. To test this hypothesis,
LDL susceptibility to copper-mediated oxidation was measured in 24 patients with sickle-cell
anemia and 48 control subjects. Sickle-cell LDL was more susceptible to oxidation than
control LDL, measured by a 22% shorter mean lag time between LDL exposure to CuSO4 …