Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients
D Nebor, C Broquere, K Brudey, D Mougenel… - Blood Cells, Molecules …, 2010 - Elsevier
The aim of this study was to identify possible risk factors for albuminuria, an early marker of
sickle cell anemia (SCA) glomerulopathy, in a cohort of 189 SCA adult patients followed at
the Sickle Cell Center of Guadeloupe, a French Caribbean island. Biological parameters
obtained at baseline, α-globin gene status, and βS haplotypes were compared in patients
stratified accordingly to graded albuminuria. Abnormal albumin excretion rate was detected
in half of the studied adult patients and macroalbuminuria occurred in 21.6%. Graded …
sickle cell anemia (SCA) glomerulopathy, in a cohort of 189 SCA adult patients followed at
the Sickle Cell Center of Guadeloupe, a French Caribbean island. Biological parameters
obtained at baseline, α-globin gene status, and βS haplotypes were compared in patients
stratified accordingly to graded albuminuria. Abnormal albumin excretion rate was detected
in half of the studied adult patients and macroalbuminuria occurred in 21.6%. Graded …