Association of alpha-thalassemia, TNF-alpha (-308G> A) and VCAM-1 (c. 1238G> C) gene polymorphisms with cerebrovascular disease in a newborn cohort of 411 …
AR Belisário, FL Nogueira, RS Rodrigues… - Blood Cells, Molecules …, 2015 - Elsevier
Cerebrovascular disease (CVD) is a severe complication associated with sickle cell anemia.
Abnormal transcranial Doppler (TCD) identifies some children at high risk, but other markers
would be helpful. This cohort study was aimed at evaluating the effects of genetic
biomarkers on the risk of developing CVD in children from Minas Gerais, Brazil. Clinical and
hematological data were retrieved from children's records. Outcomes studied were overt
ischemic stroke and CVD (overt ischemic stroke, transient ischemic attack, abnormal TCD, or …
Abnormal transcranial Doppler (TCD) identifies some children at high risk, but other markers
would be helpful. This cohort study was aimed at evaluating the effects of genetic
biomarkers on the risk of developing CVD in children from Minas Gerais, Brazil. Clinical and
hematological data were retrieved from children's records. Outcomes studied were overt
ischemic stroke and CVD (overt ischemic stroke, transient ischemic attack, abnormal TCD, or …