Alpha thalassemia is associated with decreased risk of abnormal transcranial Doppler ultrasonography in children with sickle cell anemia
LL Hsu, ST Miller, E Wright, A Kutlar… - Journal of pediatric …, 2003 - journals.lww.com
Purpose: Cerebrovascular complications of sickle cell disease (SCD) are common, but the
risk factors remain unclear. The multicenter Stroke Prevention Trial in Sickle Cell Anemia
(STOP) provided an opportunity to examine alpha thalassemia-2 as a modifying risk factor,
using abnormal transcranial Doppler ultrasonography (TCD) as a surrogate marker for
cerebrovascular disease. The authors hypothesized that children with abnormal TCD are
less likely to have alpha thalassemia-2, and an increased hemoglobin level accounts for this …
risk factors remain unclear. The multicenter Stroke Prevention Trial in Sickle Cell Anemia
(STOP) provided an opportunity to examine alpha thalassemia-2 as a modifying risk factor,
using abnormal transcranial Doppler ultrasonography (TCD) as a surrogate marker for
cerebrovascular disease. The authors hypothesized that children with abnormal TCD are
less likely to have alpha thalassemia-2, and an increased hemoglobin level accounts for this …