Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype
PP Landburg, T Teerlink, BJ Biemond… - Blood Cells, Molecules …, 2010 - Elsevier
Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in
sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related
complications. Plasma ADMA and associated parameters were determined in 52
HbSS/HbSβ0-thalassemia and 24 HbSC/HbSβ+-thalassemia patients. As expected ADMA
levels were higher in HbSS/HbSβ0-thalassemia patients with PHT (p= 0.018), but also in
those with other hemolysis-associated complications such as leg ulcers (p= 0.012) …
sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related
complications. Plasma ADMA and associated parameters were determined in 52
HbSS/HbSβ0-thalassemia and 24 HbSC/HbSβ+-thalassemia patients. As expected ADMA
levels were higher in HbSS/HbSβ0-thalassemia patients with PHT (p= 0.018), but also in
those with other hemolysis-associated complications such as leg ulcers (p= 0.012) …