[HTML][HTML] Elevated tricuspid regurgitant jet velocity in children and adolescents with sickle cell disease: association with hemolysis and hemoglobin oxygen …
CP Minniti, C Sable, A Campbell, S Rana… - …, 2009 - ncbi.nlm.nih.gov
CP Minniti, C Sable, A Campbell, S Rana, G Ensing, N Dham, O Onyekwere, M Nouraie…
haematologica, 2009•ncbi.nlm.nih.govBackground Elevation of echocardiography-determined tricuspid regurgitant jet velocity
predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell
disease. The definition, prevalence and clinical correlates of elevated jet velocity have not
been established in pediatric patients. The present study tested the hypotheses that
elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and
hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion …
predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell
disease. The definition, prevalence and clinical correlates of elevated jet velocity have not
been established in pediatric patients. The present study tested the hypotheses that
elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and
hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion …
Abstract
Background
Elevation of echocardiography-determined tricuspid regurgitant jet velocity predicts high systolic pulmonary artery pressure and early mortality in adults with sickle cell disease. The definition, prevalence and clinical correlates of elevated jet velocity have not been established in pediatric patients. The present study tested the hypotheses that elevated jet velocity affects 10% of pediatric patients, is associated with both hemolysis and hypoxia, and has clinical correlates with acute chest syndrome, stroke, transfusion requirement and abnormal 6-minute walk test results.
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