Cellular adhesion and the endothelium: E-selectin, L-selectin, and pan-selectin inhibitors
MJ Telen - Hematology/Oncology Clinics, 2014 - hemonc.theclinics.com
Sickle cell disease is characterized by episodic, acutely painful vasoocclusive episodes. The
pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive
interactions involving erythrocytes (RBCs), the endothelium, and leukocytes, including
neutrophils, monocytes, and lymphocytes. Platelets likely also contribute to the
vasoocclusive process that characterizes SCD (Fig. 1). All hematopoietic cells, as well as
endothelial cells, express multiple adhesion molecules, and many of these have been …
pathophysiology of vasoocclusion is thought to involve a wide variety of adhesive
interactions involving erythrocytes (RBCs), the endothelium, and leukocytes, including
neutrophils, monocytes, and lymphocytes. Platelets likely also contribute to the
vasoocclusive process that characterizes SCD (Fig. 1). All hematopoietic cells, as well as
endothelial cells, express multiple adhesion molecules, and many of these have been …