Adenosine deaminase–adenosine pathway in hemolysis-associated pulmonary hypertension
SP Tofovic, EK Jackson, O Rafikova - Medical hypotheses, 2009 - Elsevier
Hemolysis-associated pulmonary hypertension (HA-PH) is a serious clinical complication of
various hemolytic disorders, and pulmonary hypertension (PH) is considered the greatest
risk factor for death in patients with a hemolytic disorder. It is now well established that
hemolysis causes the release of soluble hemoglobin and arginase from injured erythrocytes
into plasma. This leads to nitric oxide (NO) deficiency, oxidative stress and a state of
endothelial dysfunction that is associated with clinical development of PH. We challenge this …
various hemolytic disorders, and pulmonary hypertension (PH) is considered the greatest
risk factor for death in patients with a hemolytic disorder. It is now well established that
hemolysis causes the release of soluble hemoglobin and arginase from injured erythrocytes
into plasma. This leads to nitric oxide (NO) deficiency, oxidative stress and a state of
endothelial dysfunction that is associated with clinical development of PH. We challenge this …