Inhaled nitric oxide attenuates the adverse effects of transfusing stored syngeneic erythrocytes in mice with endothelial dysfunction after hemorrhagic shock
C Lei, B Yu, M Shahid, A Beloiartsev… - The Journal of the …, 2012 - pubs.asahq.org
Background The authors investigated whether transfusion with stored erythrocytes would
increase tissue injury, inflammation, oxidative stress, and mortality (adverse effects of
transfusing stored erythrocytes) in a murine model of hemorrhagic shock. They tested
whether the adverse effects associated with transfusing stored erythrocytes were
exacerbated by endothelial dysfunction and ameliorated by inhaling nitric oxide. Methods
The authors studied mice fed a high-fat diet (HFD-fed; to induce endothelial dysfunction) or a …
increase tissue injury, inflammation, oxidative stress, and mortality (adverse effects of
transfusing stored erythrocytes) in a murine model of hemorrhagic shock. They tested
whether the adverse effects associated with transfusing stored erythrocytes were
exacerbated by endothelial dysfunction and ameliorated by inhaling nitric oxide. Methods
The authors studied mice fed a high-fat diet (HFD-fed; to induce endothelial dysfunction) or a …