[HTML][HTML] Cell cycle-dependent regulation of pyrimidine biosynthesis
FD Sigoillot, JA Berkowski, SM Sigoillot… - Journal of Biological …, 2003 - ASBMB
De novo pyrimidine biosynthesis is activated in proliferating cells in response to an
increased demand for nucleotides needed for DNA synthesis. The pyrimidine biosynthetic
pathway in baby hamster kidney cells, synchronized by serum deprivation, was found to be
up-regulated 1.9-fold during S phase and subsequently down-regulated as the cells
progressed through the cycle. The nucleotide pools were depleted by serum starvation and
were not replenished during the first round of cell division, suggesting that the rate of …
increased demand for nucleotides needed for DNA synthesis. The pyrimidine biosynthetic
pathway in baby hamster kidney cells, synchronized by serum deprivation, was found to be
up-regulated 1.9-fold during S phase and subsequently down-regulated as the cells
progressed through the cycle. The nucleotide pools were depleted by serum starvation and
were not replenished during the first round of cell division, suggesting that the rate of …