Innate lymphoid cells—how did we miss them?

JA Walker, JL Barlow, ANJ McKenzie - Nature reviews immunology, 2013 - nature.com
JA Walker, JL Barlow, ANJ McKenzie
Nature reviews immunology, 2013nature.com
Innate lymphoid cells (ILCs) are newly identified members of the lymphoid lineage that have
emerging roles in mediating immune responses and in regulating tissue homeostasis and
inflammation. Here, we review the developmental relationships between the various ILC
lineages that have been identified to date and summarize their functions in protective
immunity to infection and their pathological roles in allergic and autoimmune diseases.
Abstract
Innate lymphoid cells (ILCs) are newly identified members of the lymphoid lineage that have emerging roles in mediating immune responses and in regulating tissue homeostasis and inflammation. Here, we review the developmental relationships between the various ILC lineages that have been identified to date and summarize their functions in protective immunity to infection and their pathological roles in allergic and autoimmune diseases.
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