Upregulation of the apoptosis-related inflammasome in cardiac allograft rejection
T Seto, S Kamijo, Y Wada, K Yamaura… - The Journal of Heart and …, 2010 - Elsevier
BACKGROUND: Inflammation is a major factor in cardiac allograft rejection. Accumulating
reports have demonstrated an important role of the inflammation-induced adaptor complex,
called the inflammasome, in the field of immunology. The apoptosis-associated, speck-like
protein containing a caspase recruitment domain (ASC) is an adaptor protein that forms the
inflammasome and regulates caspase-1–dependent generation of inflammatory cytokines.
The aim of the present study was to determine how ASC is associated with the development …
reports have demonstrated an important role of the inflammation-induced adaptor complex,
called the inflammasome, in the field of immunology. The apoptosis-associated, speck-like
protein containing a caspase recruitment domain (ASC) is an adaptor protein that forms the
inflammasome and regulates caspase-1–dependent generation of inflammatory cytokines.
The aim of the present study was to determine how ASC is associated with the development …