The effect of interstimulation interval on the assessment and stability of kindled seizure thresholds
FG Freeman, MF Jarvis - Brain research bulletin, 1981 - Elsevier
Two experiments were conducted to investigate the importance of the interstimulus interval
(ISI) in the assessment of kindled seizure thresholds using an ascending method of limits. A
third experiment examined the effect of varying the interval between successive threshold
tests on threshold stability. No differences in afterdischarge (AD) or motor seizure (MS)
threshold were observed when the ISI was either five minutes or 48 hours. However, a 30
second ISI yielded significantly higher AD and MS thresholds and shorter seizure duration …
(ISI) in the assessment of kindled seizure thresholds using an ascending method of limits. A
third experiment examined the effect of varying the interval between successive threshold
tests on threshold stability. No differences in afterdischarge (AD) or motor seizure (MS)
threshold were observed when the ISI was either five minutes or 48 hours. However, a 30
second ISI yielded significantly higher AD and MS thresholds and shorter seizure duration …