Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic …
BACKGROUND/AIMS: Not all alcoholics develop liver disease (ALD). Thus, excessive
ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis
(ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed
that gut-derived, circulating endotoxin is the necessary co-factor for ASH. But, it is not known
whether endotoxemia is the consequence or the trigger for ALD. Accordingly, the aim of the
current study was to determine whether endotoxemia occurs prior to development of ASH …
ethanol consumption is necessary, but not sufficient, to induce alcoholic steatohepatitis
(ASH) and ALD. Since endotoxemia is present in patients with ALD, it has been proposed
that gut-derived, circulating endotoxin is the necessary co-factor for ASH. But, it is not known
whether endotoxemia is the consequence or the trigger for ALD. Accordingly, the aim of the
current study was to determine whether endotoxemia occurs prior to development of ASH …